A meta-analysis of 8 double-blind, randomized, placebo-controlled, manufacturer-funded trials (N = 746) of low to very low quality revealed effectiveness of P. sidoides (EPs 7630) alcoholic extract for relieving acute bronchitis symptoms in adults and children, and possibly sinusitis in adults as well. Douros, A.; Bronder, E.; Andersohn, F. et al. Similar results were observed in a Salmonella reversion test. The plant species has also been investigated for use in treating gastritis. Anheyer, D.; Cramer, H.; Lauche, R. et al. Additionally, the Medicines and Healthcare Products Regulatory Agency has extended warnings to several companies to stop selling DMAA-containing products in the UK.40. Can Lemon Balm Help Reduce Stress and Boost Your Health? In contrast, P. reniforme has magenta red to black flowers, kidney-shaped leaves, and white to green pollen.2, 3 Both plant species may be found along the seacoast and interior portions of South Africa. Height: 6 to 40 inches (15 to 100 cm). Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. The genus Pelargonium contains about 270 species placed under 16 sections, in which the section Pelargonium has 26 species (Miller, 2002; Rajeswara Rao, 2013a). She is an in-patient physician at Novant Health Huntersville Medical Center in North Carolina. This is only a brief summary of general information about this product. The Plants Database includes the following 14 species of Pelargonium . Clinical trials of EPs 7630 in acute bronchitis have been conducted in children and adults.25, 26, 27, 28, 29, 30, 31 The primary outcome or review of efficacy for most of the trials are changes in the Bronchitis Severity Score (ie, coughing, expectoration, chest pain, dyspnea, wheezing) from baseline versus the last observation (ie, final observation typically within 1 week). Herbal Medicine in Children With Respiratory Tract Infection: Systematic Review and Meta-Analysis. This product may be unsafe when used before surgery or other medical procedures. This information relates to an herbal, vitamin, mineral or other dietary supplement. Time to first exacerbation was significantly prolonged by a median of 14 days with EPs 7630 (P = 0.005), the number of moderate versus mild exacerbations was significantly lower (P < 0.0001), and fewer patients overall on the study treatment experienced exacerbations. No serious adverse reactions were reported.32, 33, EPs 7630 inhibited Helicobacter pylori growth and reduced bacterial adherence to gastric epithelial adrenogenital syndrome cells. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. As with the previous studies, there was some evidence of a beneficialÂ effect, but the results were largely skewed by the poor quality of the research. Cochrane Database Syst Rev. Pelargonium sidoides Pelargonium sidoides, also known as African geranium, is a plant-derived pharmaceutical used to treat acute bronchitis. Several fairly large clinical trials examine the plant's efficacy in treating acute bronchitis, common cold, and pharyngitis or sore throat.17, The extracts of both Pelargonium species have modest direct antibacterial activity, with isolated coumarins and phenolics having minimum inhibitory concentration values from 200 to 1,000 mcg/mL in agar dilution assays versus common test bacteria.18 Unsaturated fatty acids from the roots, especially linoleic acid, had antimycobacterial activity at 2 mcg/mL in vitro.7, Immune stimulation of the host is a potential course for antimycobacterial activity. In Germany, pharmacovigilance studies document allergic reactions associated with the use of Pelargonium extract. Sparsely branched stems grow from the base and display deep red to black flowers, and the species is distinguished by the cordate or heart-shaped leaves. One report recommends caution if used during pregnancy.36, An interaction may be possible when patients are receiving anticoagulant medications (eg, warfarin) or antiplatelet drugs (eg, aspirin). If you decide to take pelargonium (especially highly concentrated extracts), call your doctor if you experience any signs of liver toxicity, including fatigue, stomach pain, nausea, dark urine, light stools, or yellow skin or eyes. Due to the lack of safety research, pelargonium remedies should be not be used by children, pregnant women, or nursing mothers. Do Agaricus Mushrooms Have Health Benefits? 4.5 out of 5 stars (3,259) 3,259 reviews $ 14.99. Dietary supplements are not subject to rigorous testing and research in the United States. Adorned with pointed lobes, they resemble those of Ivy (Hedera), hence the common name. DOI: 10.1016/j.phymed.2007.11.023. Trailing types have green ivy-shaped leaves and others are wavy-margined. There is also some concern that the long-term or excessive use of pelargonium may cause liver injury. No reports on toxic effects of EPs 7630 are available. Important: The information below refers to products available in the United States that contain pelargonium. P. sidoides is a small geranium-like plant that grows in a rosette from thick and very dark brown underground roots that grow up to 15 cm in length. Native: Southern Africa, Australasia, Middle East. This information should not be used to decide whether or not to take this product. Common Names: Geranium, Pelargonium, Scented Geranium, Storksbill, Rose Geranium. â¸ 2020 About, Inc. (Dotdash) â All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. You may think that red, pink, or white annual flowering plants with thick pleated leaves are called \"geraniums,\" since everyone calls them that. PELARGONIUM PASSION The first pelargonium in Europe was Pelargonium triste.It arrived at Leiden Botanical Gardens in the Netherlands around 1600, with cuttings taken to France and England soon after. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Select one or more newsletters to continue. Full instructions are sent out with all our pelargoniums. Pelargonium, a flowering plant from South Africa, gets confused with geranium because its ivy-shaped leaves are similar. Thâ¦ When used in traditional African medicine, the South African geranium is often referred to as umckaloabo, kaloba, or umcka. Geraniums (Pelargonium x hortorum) make popular bedding plants in the garden, but theyâre also commonly grown indoors or outside in hanging baskets.Growing geranium plants is easy as long as you can give them what they need. How to Grow Geraniums. One clinical trial administered 4.5 mL 3 times daily for 7 days, corresponding to a total daily dose of plant material of approximately 1.2 g.25 A second trial used the same dosing schedule.26 Other dosage regimens used in clinical trials include the following17: Other Dosage Regimens Used in Clinical Trials. Icon - Arrow Left The genus Pelargonium comprises approximately 280 known species, of which 80% are grown in the interior of South Africa.1 Both of the title plant species are distinguished by the color of the flowers, the shape of the leaves, and the pollen color. Everything you need to know about choosing the right pelargonium for you. DOI:Â 10.3390/ijms17010114. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Read our, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Lana Butner, ND, LAc, Joshua McCullough / Photolibrary / Getty Images, Rose Geranium Benefits, Side Effects, and Alternatives. Native Introduced Native and Introduced. Herb Pharm Certified Organic Umckaloabo Liquid Extract for Respiratory System Support - 1 Ounce. Pelargonium. Pelargonium sidoides helps reduce cold symptoms. However, a study in rats documented no pharmacokinetic or pharmacodynamic interactions between EPs 7630 and warfarin.36, 37, Clinical trials enrolling nearly 2,500 adults and children document mostly allergic reactions or GI complaints (eg, gastric pain, heart burn, nausea, diarrhea). To ensure quality and safety, only purchase pelargonium products from a reputable manufacturer with an established brand presence. Because of poor seed viability, a clonal method of propagation has been developed to reduce pressure on natural populations.4, The plant species indigenous to areas of South Africa are widely used by traditional healers of the Zulu, Basuto, Xhosa, and Mfengi tribes to treat dysentery, diarrhea, hepatic complaints, wounds, colds, fatigue, fevers, generalized weakness, and infections of the respiratory tract including tuberculosis.4, 5 Western use of the P. sidoides and P. reniforme species to treat tuberculosis is traced back to the Englishman Major Charles Stevens in 1897 when he was treated by a tribal healer with an extract from the roots of Pelargonium species.2, Originally, the plant source of the drug was identified as P. reniforme; however, further botanical investigations discovered the closely related species P. sidoides, which is now predominately used for therapeutic purposes.2. Carl Linnaeus originally included all the species in one genus, Geranium, and they were later separated into two genera by Charles Louis L'Héritier de Brutelle in 1789. Native to South Africa, Pelargonium peltatum (Ivy Geranium) is a trailing, evergreen perennial with fleshy, glossy, bright green leaves, 2-3 in. You should also avoid pelargonium if you have liver disease, are a heavy drinker, or take medications metabolized by the liver. Avoid use with hypersensitivity to any of the components in EPs 7630 or Pelargonium species. No animal toxicology studies have been reported. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In another review published in Academic Pediatrics in 2018, scientists evaluated 11 studies investigating the effectiveness of echinacea, pelargonium, and other herbal medicines in treating respiratory tract infections in kids. across (5-7 cm). This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Case reports of fatalities linked to the use of a product containing the Pelargonium extract 1,3-dimethylamylamine (DMAA) have led to DMAA-containing products being banned by the US Department of Defense from military bases and resulted in a complete ban by the New Zealand Ministry of Health. Capacity, P. sidoides extracts are known to neutralize certain bacteria and viruses stars ( 3,259 ) 3,259 reviews 14.99. And Natural health products in the 1970s in Australia and have been sprayed with pesticides or exposed to fertilizers... In shades of red, pink, lavender or white appear from spring through fall they produce of. The UKâs leading gardening charity remedies are typically sold as extracts,,. To have no effect for bronchitis and pharyngitis, lavender or white appear from through. 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